|

Merck stock trails market as 2025 guidance disappoints, largely due to China

  • MRK stock sold off more than 10% during Tuesday's session.
  • Merck reported Q4 sales and profit that beat Wall Street consensus.
  • 2025 guidance was at least ~$2 billion below consensus.
  • Shipments of Gardasil to China and a milestone payment on LM-299 are culprits.

Merck (MRK) stock sank like a stone on Tuesday after the pharmaceutical giant posted poor guidance for the rest of the year. Shares of the New Jersey-based maker of oncology best-seller Keytruda fell over 10% mid-session despite the company posting beats on the top and bottom lines in the fourth quarter.

The Dow Jones Industrial Average (DJIA), which holds Merck as a constituent, rose after a morning pullback. China responded to the Trump administration’s 10% tariff on its imports with its own smaller tariff package on US coal and other goods. China also opened an antitrust case into Alphabet (GOOGL), the timing of which is viewed as part and parcel of the trade war, in addition to reopening a prior case on Nvidia.

Merck earnings news: Q4 beats, but 2025 guidance hurts

Merck management provided shareholders with 2025 guidance for between $64.1 billion and $65.6 billion in full-year sales. This range was noticeably below the Wall Street consensus for roughly $67.4 billion.

Likewise, guidance for earnings per share (EPS) of  $8.88 to $9.03 missed the $9.21 consensus by a significant margin.

In its own earnings release on Tuesday morning, fellow pharma giant Pfizer (PFE) also gave guidance that slightly underperformed market expectations. Most pharma stocks have been in retreat since Donald Trump selected vaccine and pharma sceptic Robert F. Kennedy, Jr. as his top health nominee. 

But Merck’s fourth-quarter was quite successful. It reported adjusted EPS of $1.72, which was $0.04 ahead of consensus. Revenue of $15.62 billion was more than $100 million above the average projection. 

Management partially blamed a one-time charge of about $0.09 per share related to a milestone payment to partner LaNova. The latter Chinese company is the developer of LM-299, a bispecific antibody used to treat cancer progression, which Merck markets globally. 

Another factor in the reduced profit outlook is that Merck is pausing sales of its HPV vaccine Gardasil to China through the middle of the year. 

Merck earnings news

Merck stock has moved back to the early October lows of last fall. MRK stock did recover somewhat toward the end of Tuesday's session, but shares are now trending well below moving averages. 

The real support appears to stem from the middle of 2022 when the $83 to $85 zone saw a lot of volume. Buyers will likely wait until MRK descends to this level before picking up shares.

MRK weekly stock chart

Premium

You have reached your limit of 3 free articles for this month.

Start your subscription and get access to all our original articles.

Subscribe to PremiumSign In

Author

Clay Webster

Clay Webster

FXStreet

Clay Webster grew up in the US outside Buffalo, New York and Lancaster, Pennsylvania. He began investing after college following the 2008 financial crisis.

More from Clay Webster
Share:

Markets move fast. We move first.

Orange Juice Newsletter brings you expert driven insights - not headlines. Every day on your inbox.

By subscribing you agree to our Terms and conditions.

Editor's Picks

EUR/USD recovers to 1.1750 region as 2025 draws to a close

Following the bearish action seen in the European session on Wednesday, EUR/USD regains its traction and recovery to the 1.1750 region. Nevertheless, the pair's volatility remains low as trading conditions thin out on the last day of the year.

GBP/USD stays weak near 1.3450 on modest USD recovery

GBP/USD remains under modest beairsh pressure and fluctuates at around 1.3450 on Wednesday. The US Dollar finds fresh demand due to the end-of-the-year position adjustments, weighing on the pair amid the pre-New Year trading lull. 

Gold retreats to $4,300 area, looks to post monthly gains

Gold stays on the back foot on the last day of 2025 and trades near $4,300, possibly pressured by profit-taking and position adjustments. Nevertheless, XAU/USD remains on track to post gains for December and extend its winning streak into a fifth consecutive month.

Bitcoin, Ethereum and XRP prepare for a potential New Year rebound

Bitcoin, Ethereum, and Ripple are holding steady on Wednesday after recording minor gains on the previous day. Technically, Bitcoin could extend gains within a triangle pattern while Ethereum and Ripple face critical overhead resistance. 

Economic outlook 2026-2027 in advanced countries: Solidity test

After a year marked by global economic resilience and ending on a note of optimism, 2026 looks promising and could be a year of solid economic performance. In our baseline scenario, we expect most of the supportive factors at work in 2025 to continue to play a role in 2026.

Crypto market outlook for 2026

Year 2025 was volatile, as crypto often is.  Among positive catalysts were favourable regulatory changes in the U.S., rise of Digital Asset Treasuries (DAT), adoption of AI and tokenization of Real-World-Assets (RWA).