The Dow Jones industrial average fell 84 points, or 0.67%, to 12,519. The Standard & Poor's 500 Index dropped 13 points, or 0.99%, to 1,328. The Nasdaq Composite lost 44 points, or 1.53%, to 2,843.
In the macroeconomic domain, the number of USworkers filing for jobless benefits fell more than economists expected to the lowest level in more than four years last week. US jobless claims fell by 26,000 to 350,000 last week.
European stocks were broadly lower, with the Stoxx Europe 600 losing 1.3%, despite an unexpected increase in May industrial production in the euro zone.
Gold fell 1.2% to $1556 an ounce, while crude-oil futures dropped 1.5% to $84.55 a barrel.